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In China, supportive policies like accelerated approval pathways for urgently needed orphan drugs (UNOD) and Care for Rare Diseases Encouragement (CARE) plan 28 , have been implemented to improve access to therapies for rare conditions
We also measured the glutathione redox state in the cad2 mutant, using the Grx1-roGFP2 construct introgressed in cad2 (Meyer et al., 2007)
As mediators of cellular stress, the activation of the MAPK family also suppresses the expression of downstream ROS clearance genes and promotes the secretion of pro-inflammatory cytokines (330, 331)
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