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IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

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Furthermore, these medications require long-term use to sustain their benefits, leading to dependency and substantial financial costs due to their high price

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105 Besides, a cyclic EGFR-binding peptide (CMYIEALDKYAC) elicited preferential accumulation in EGFR-overexpressing malignancies, which in turn produced significantly higher photocytotoxicity and effectively inhibited tumor growth after photodynamic therapy