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This protective effect was observed in both diabetic mice and in lab-grown kidney cells, and it works independently of tirzepatides ability to lower blood sugar
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Nef promotes neuropathology by upregulating CCL2 in microglia and enhancing IL-6 and IL-8 production in astrocytes [137,138,139], while also activating NADPH oxidase in phagocytes, thereby exacerbating neuroinflammation, myelin damage, and neuronal injury [134, 140]
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