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Mistake 3: Believing "it makes you go blind." Sudden vision loss (NAION) is a real but rare signal, it is absent in several large studies, and it is not confirmed to be caused by the drug (Liu 2025)

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Most K cells express PC1/3, which cleaves proGIP at Arg65, resulting in the biologically active GIP(142) (Ugleholdt et al., 2006) and stored in secretory granules (450 nm) (Meier et al., 2004a), GIP promotes nutrient-stimulated insulin secretion and increases glucagon secretion in the fasted state but not in patients with type 2 diabetes ( The physiological concentrations of the peptide hormones GIP, GLP-1, and GLP-2, are tightly controlled by the nutrient-sensing abilities of their respective enteroendocrine cells

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REDEFINE 3 evaluates cardiovascular outcomes (~7,000 participants, event-driven)

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