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Nitrofurantoin already causes GI side effects in approximately 10 to 15 percent of patients, and Macrodantin (the immediate-release form) more so than Macrobid

Aggregated -synuclein inhibits mitochondrial bioenergetics, resulting in decreased ATP generation, increased oxidative stress, and poor calcium buffering [8]

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FDA action is the next regulatory event The meeting has ended, but none of its recommendations changed the final 503A regulation by itself