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Side effects: Very few reports so far, but insufficient long-term human data

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Intriguingly, in the trx3 , trr2 , and prx1 strains we observed either no E GSH response ( prx1 ) or an E GSH response that was greatly decreased compared to wildtype cells ( trx3 , trr2 ), following the addition of exogenous H 2 O 2 at an initial concentration of 1 mM (Fig 3A)