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It relies heavily on glutathione to bind to toxins and heavy metals, making them water-soluble so they can be excreted safely
Firstly, it exhibits strong antioxidant activity by scavenging free radicals and reducing oxidative stress
Apart from these factors, comorbid conditions associated with DM, such as obesity (Samuels et al., 2019), dyslipidemia (Podrez et al., 2007), and non-alcoholic fatty liver disease (NAFLD) also promote the prothrombotic state in DM ( Platelet hypersensitivity is characterized by increased platelet microparticles, ROS, platelet activation complex-1 (PAC-1) binding, P-selectin, thromboxane B2 (TXB2), and enhanced platelet spreading, number, mean platelet volume (MPV), and high aggregation to low concentrations of agonists
Immune-deficient NOD-SCID-IL2RG-/- mice (NSI mice, GIBH) were used as recipients for in vivo transplantation experiments
Gupta, P
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