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Doubling GLP-1 receptor stimulation significantly increases nausea, vomiting, dehydration, and gastrointestinal distress

Reported or theoretically plausible side effects of CJC 1295 and ipamorelin include: Water retention and peripheral oedema Flushing, headache, and dizziness, particularly after injection Tingling or numbness in the extremities Elevated IGF-1 levels, which over time may theoretically increase the risk of certain cancers, though a direct causal link has not been established in clinical studies [13] [14] Impaired glucose tolerance or insulin resistance GH excess and GH secretagogues are more commonly associated with raised blood glucose rather than hypoglycaemia

Twelve percent of American adults now take GLP-1 drugs for weight loss

Red and itchy injection sites are particularly common with compounded formulations, and some users have speculated that the B12 component, with its distinctive color, may contribute to local irritation

pubchem.ncbi.nlm.nih.gov/compound/Unii-qhk6Z47gtg National Center for Biotechnology Information