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Regain begins within 2 to 3 weeks of last dose Appetite returns to pre-treatment levels or higher (rebound hyperphagia) Weight regain of 1 to 2 pounds per week for the first 8 to 12 weeks Patients report feeling "more hungry than before I started" Typically occurs in patients who made minimal dietary or behavioral changes during treatment Regain trajectory matches or exceeds the STEP 1 extension trial data (two-thirds of weight back within one year) Pattern 2: Partial regain with stabilization (approximately 45% of discontinuations)

By inhibiting macrophage infiltration, calcium deposition, extracellular matrix remodeling and the proliferation of vascular smooth muscle cells