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In the pediatric studies, the increase in height velocity produced by sermorelin was less than that produced by once-daily subcutaneous somatropin (recombinant GH itself)
The mechanism of action has not changed, only the addition of a nausea-dampening cofactor that may make the critical early weeks and dose escalation phases manageable
Garcia-Larsen V, Potts JF, Omenaas E, et al
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Stimulating GLP-1R in BMSCs triggers the buildup of nuclear -catenin, which, in turn, activates osteogenic genes by binding with TCF7L12
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