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the patients who provided their tissue for research

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Western blotting Cells or tissue samples were lysed on ice using RIPA buffer (TargetMol,USA;C0045) supplemented with protease and phosphatase inhibitors

60 Senescence Senescence is the permanent arrest of the cell cycle, and it is well accepted as one of the major barriers to inhibiting tumorigenesis

12 Neurobiological changes are evident in the premonitory stage and include alterations in nociceptive signalling, while the headache phase involves activation of the trigeminovascular system and, in migraine with aura, a cortical spreading depression-like event characterised by an electrophysiological wave of excitation followed by inhibition in cortical neurons