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While a mild rash around this area can be normal, it could also be a sign of a serious allergic reaction if it gets worse or doesnt go away

Note: These are research observations, not prescriptions

And importantly, if unintended weight loss occurs in a lean patient, we stop or lower the dose

That said, not all patients experience such drastic results, and lack of efficacy is cited as a top driver behind discontinued use of these drugs among both patients and physicians

Neurological symptoms such as tingling or numbness are more commonly associated with B12 deficiency rather than excess and warrant medical assessment