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[14] A 2018 systematic review and meta-analysis of 12 randomized controlled trials found "supplementation significantly decreases depressive symptoms compared with placebo/no intervention, while offering a comparable effect with that of established antidepressant agents with fewer adverse effects." The review also indicates that "the effect of ALC in younger subjects was not more effective than placebo in improving these symptoms." indicating a need for more research explaining the age/effect relation
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Upon ferroptosis induction, Grx2 becomes activated by disassembly of the FeS-cluster introducing the FeS-cluster bound in Grx2 dimers as a ferroptosis sensor
The condition occurs when blood supply to the optic nerve is compromised, leading to ischemia and damage to the nerve fibers
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