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Research published in Fertility and Sterility found that women with PCOS treated with metabolic agents showed significant reductions in BMI and total testosterone levels compared to placebo groups

Kahan, S., & Manson, J

Theoretical and reported concerns Off-target cell death: no compound is perfectly selective, so healthy cells with temporarily high FOXO4 could be affected in theory

Exercise integration Resistance training 3-4 times per week is the single most important non-medication intervention for preserving muscle during tirzepatide-assisted weight loss

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