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Anemia from another cause, thyroid disease, iron deficiency, folate deficiency, inflammatory disease, and metabolic contributors can all produce overlapping complaints, as can medication effects, sleep disorders, and neurologic conditions
However, the foundational mechanism paper (Benoist et al., 2014 in J Pharmacol Exp Ther) establishing Dihexas HGF/c-Met pathway activation was formally retracted in April 2025 after being flagged since 2021
Treatment can still help but results may be more limited
Treatment limited body-weight and fat-mass gain without changing food intake or lean mass
Mental Focus and Cognitive Function The demands of high-level athletics arent just physical mental sharpness is equally important
