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Cocaine binds with high affinity to the norepinephrine transporter (NET) on the presynaptic nerve terminal (Kd 0.3 M), acting as a transmembrane physical plug that inhibits reuptake of norepinephrine

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If GI side effects persist beyond the adjustment period or are severe enough to significantly impact quality of life, dose adjustment may be warranted

Stability: Unlike many peptides that break down quickly, BPC-157 is notable for its stability in human gastric juice, meaning it may be effective orally as well as through injection