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For patients with moderate renal insufficiency (CrCl greater than or equal to 30 to less than 50 mL/min, approximately corresponding to serum creatinine levels of greater than 1.7 to less than or equal to 3.0 mg/dL in men and greater than 1.5 to less than or equal to 2.5 mg/dL in women), the dose of Januvia is 50 mg once daily

It is a flat $319/month on the monthly plan, $249/mo on the 12-week plan, or as low as $199/mo on the 52-week plan

Indirect mechanismsincluding reduced saliva production from decreased fluid intake, gastrointestinal side effects, and ketosis during weight lossmay contribute to bad breath

Keep in mind that these numbers are averages for the maximum dose of each medication