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Avoid competitive sports for 5 to 6 months to allow the new graft to get incorporated into the knee joint

Activation of the mevalonate pathway will not only result in an increased cholesterol synthesis, but also in an upregulation of the expression as well as post-translational modifications of small GTPases, which will increase cellular metabolism, proliferation, and migration [111, 113, 114]

It needs to be however noted that a recent PET study [66] did not replicate Nakatomi et al