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LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al
Rita Cardoso B, Apolinario D, da Silva Bandeira V, Busse AL, Magaldi RM, Jacob-Filho W et al
The sensitivity of the forward rate constants for the superoxide formation reaction, k p2 , and the oxygen concentration parameter, k O2 , proved to be the most sensitive globally with respect to total effects, highlighted in Fig
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(PubMed) Xiang GD, Sun HL, Zhao LS, Hou J, Yue L, Xu L
