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I enlisted two Harvard colleagues, Ron Kahn and Bruce Spiegelman, and together we outlined an approach that included a search for novel insulin analogues and insulin sensitizing agents, identifying the protein responsible for obesity in genetically obese mice (six years before identification of the ob gene), and exploration of gut factors regulating metabolism, such as the incretins that enhanced insulin secretion
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Potential long-term effects could include joint pain and increased risk of diabetes due to altered glucose metabolism
Dialysis dependence or an estimated glomerular filtration rate below 30 mL min1 1.73 m2 represents an absolute contraindication unless the infusion is placed immediately before dialysis under nephrology supervision
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