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What, then, is microdosing
This could enable the treatment of hypoxic tumors, which represent a major challenge in anticancer drug development
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45 Liver cytochrome P450 (CYP450) enzymes regulate the biotransformation of targeted agents (e.g., imatinib, erlotinib), and polymorphisms in these enzymes can result in therapeutic failure or toxicity
For instance, while liraglutide may utilize a simple up-titration schedule over several weeks, exenatide could require more frequent dose adjustments dependent on glucose regulation and weight fluctuations
