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What this tells us about early dosing The missed dose guidelines reveal that the acceptable dosing window ranges from a minimum of 72 hours to a maximum of roughly 11 days (168 + 96 hours)
The baseline ALSFRS-R total score and FVC% were comparable in the 2 groups
In SURMOUNT-1, nausea occurred in 24-33% of participants (vs 10% placebo), but most cases were mild-to-moderate and occurred during dose escalation
Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, et al
Several of the proteins identified in STEP 1 and STEP 2 are known to be related to obesity and T2D pathophysiology and their associated complications, including C-reactive protein (CRP), adipokines (leptin, adiponectin), ghrelin, insulin-like growth factor binding protein (IGFBP), growth hormone receptor (GHR), neural cell adhesion molecule 1 (NCAM1) and netrin receptor (UNC5D), among others
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