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A person can carry an MTHFR or COMT variant and still have adequate current methylation, while another person with no major variant can develop low SAM, elevated SAH or impaired glutathione production
Overall, Nrf2 is fundamental for the sustenance of the GSH redox state through glutathione reductase transcriptional regulation and for cell protection against oxidative stress (Harvey et al., 2009)
Pro-caspase-1 is recruited to the complex upon inflammasome assembly and undergoes autoproteolytic cleavage to generate active caspase-1
2004 Aug 15;10(16):2311-7
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