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In mammalian cells, HIF-1 can regulate the expression of cyt c oxidasecytochrome c oxidase subunit IV (COX4) by activating the transcription of genes encoding COX42 and LON to optimize the efficiency of respiration under hypoxic conditions [113]

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Cagrilintide is a synthetic long-acting amylin analog studied as a research compound for amylin and calcitonin receptor pharmacology