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While the observed weight loss in the Look Action for Health in Diabetes study improved cardiovascular parameters, it did not reduce the morbidity and mortality associated with CVD, measured as cardiovascular events
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This overlap with the mTOR axis places MOTS-c in an interesting relationship with The Rapamycin Protocol, the most direct pharmaceutical intervention on the mTOR pathway
3 Redox-sensitive proteins: gatekeepers of cellular signaling and homeostasis Several intracellular proteins function as redox sensors, undergoing reversible modifications that enable them to alternate between active and inactive conformations
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