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This study also found that anti-doxorubicin produced inflammation and oxidative stress in the kidneys, and that doxorubicin plus apigenin increased resistance to doxorubicin in breast cancer cells via the JAK/STAT signalling pathway (162)

Early intervention provides favorable conditions for inducing diverse and sustained tumor-specific T-cell responses when tumor antigenicity is still relatively preserved and before the TME develops strong immunosuppressive traits

Journal of the American Heart Association, 15, e047893

Also, some of the other indications, like kidney disease and cardiovascular disease, show benefits irrespective of weight loss and glucose lowering, and should be continued if you have those conditions for their benefit

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