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Hydroxytyrosol as a multitarget pharmacological agent for oxidative, inflammatory and metabolic disorders

Based on preclinical and early human data, activating all three pathways is thought to reduce appetite, improve insulin sensitivity, increase energy expenditure, and support fat breakdown effects that have shown substantial weight loss results in early-phase clinical trials, including a phase 2 study published in the New England Journal of Medicine (2023)

Overall the study concluded that AOD9604 was shown to be beneficial in obese mice both with and without the beta(3)-adrenergic receptors present

BPC-157 safety considerations BPC-157 shows minimal adverse effects across extensive research use

The combination is categorically more effective than either alone