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There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH
Supplementary material The Supplementary Material for this article can be found online at: References 1 AmatullahH.Maron-GutierrezT.ShanY.GuptaS.TsoporisJ
The common ones
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Although this study makes a critical contribution to the literature, there are limitations
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