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What the Evidence Shows on Compounded Bioidentical HRT The Menopause Society (formerly NAMS) published a 2020 position statement noting: "Compounded bioidentical hormone therapy (cBHT) is not recommended over FDA-approved bioidentical hormone therapy due to concerns about safety, quality, and the lack of clinical trial data." [11] That position reflects the absence of randomized controlled trials powered to show efficacy or long-term safety for compounded formulations specifically, not for the hormones themselves

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[ref] In older adults with major depressive disorder, saffron (60mg/day) was compared to sertraline (Zoloft) for depression

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