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Long-term safety monitoring includes periodic laboratory testing, but the medication appears safe for extended use in appropriate candidates

The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

Baltimore: Lippincott Williams & Wilkins

COPD is characterized by inflammation and fibrosis of the small airways and destruction of lung parenchyma (emphysema), which eventually leads to irreversible airflow obstruction (Li et al

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