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Its mechanism involves multiple pathways that contribute to weight loss: Appetite regulation : Semaglutide acts on receptors in the brain's appetite centres, particularly the hypothalamus, reducing hunger and increasing feelings of satiety Gastric emptying : It slows the rate at which food leaves the stomach, prolonging fullness after meals Glucose regulation : It enhances insulin secretion in a glucose-dependent manner and suppresses inappropriate glucagon release The slowed gastric emptying associated with Wegovy is a primary contributor to the nausea many patients experience, particularly during dose escalation
Most people on either medication experience side effects that improve significantly after the first few weeks
Coordinating these treatments properly can help minimize the risk of adverse interactions and maximize the benefits of both
older adults (OA): mean SD age = 69.52 5.42 years, range = 6085 years, 21 females)
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