Fisher M, VandenBranden M, Findlay K, Burchell B, Thummel K, Hall S, Wrighton SA: Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank
Magn Reson Med 74:15301542 Demarest TG, Schuh RA, Waddell J, McKenna MC, Fiskum G (2016) Sex dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic-ischemic encephalopathy
From topical research: Most commonly reported observation: mild transient redness at application site (attributed to vascular activity from VEGF stimulation) No systemic adverse events reported in human topical studies at standard concentrations No evidence of carcinogenicity or mutagenicity in available in vitro models From injectable research (preclinical): At supratherapeutic doses in animal models, mild injection site reactions have been noted No organ toxicity observed in standard preclinical safety panels No immunogenicity concerns identified (consistent with its endogenous structure) Copper considerations: GHK-Cu delivers a small amount of bioavailable copper
BPC-157 is studied for tissue repair and gastrointestinal protection, TB-500 for cell migration and anti-inflammatory activity, and GHK-Cu for collagen synthesis and skin remodeling
Inhibition of GGT (105) and elevated expression of ChaC1/ChaC2 (69,79) are associated with autophagy phenotype