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ONC201, a dual inhibitor of Akt and ERK, is being evaluated in combination with paclitaxel for the treatment of platinum-resistant ovarian cancer in an ongoing phase II trial (NCT04055649)
This elevated TIMP-to-MMP ratio creates an environment where damaged tissue gets cleaned up while new tissue gets protected
Second, although this analysis included 45 studies with a fairly large sample size, the low incidence of thyroid events resulted in a wide confidence interval that reduced the certainty of our findings
doi: 10.1056/NEJMoa1612917
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