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At a molecular level, phosphatidylcholine is the only phospholipid absolutely required for the hepatic assembly and secretion of very low-density lipoproteins (VLDL)

So for NAION, knowing that by taking this medication you are putting yourself at a slight increase of that happening, though again, the chances are extremely rare. While some studies have shown a possible concern for the development of NAION, Dr

Kipnis adds

What wasnt initially realized is that GLP-1 receptors are also found in brain regions governing motivation and reward, including the nucleus accumbens, the ventral tegmental area, the amygdala, the hippocampus, and other areas

Similar guidance would likely apply to retatrutide, but this has not been formally established