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Three randomized withdrawal trials (SURMOUNT-4, STEP 1 extension, STEP 4) and a new BMJ 2026 systematic review of 37 RCTs and nearly 10,000 adults all land on the same signal
Supplemental lipoic acid also decreased the serum concentrations of some (IFN-, ICAM-1, TGF-, IL-4), but not all markers (TNF-, IL-6, MMP-9), cytokines and other inflammation (98)
\Increased NAD+ Levels: Oral forms of NAD+ precursors have been shown to significantly raise NAD+ levels in human blood
Reductions in nonfatal stroke (12%) and cardiovascular death (7%) also contributed, though these individual end points did not reach statistical significance on their own
What neither drug replaces Neither Mounjaro nor Ozempic replaces the foundations of care
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