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Preclinical studies have suggested potential biomarkers such as circulating free IGF levels, mutations of p53, BRCA1, KRAS and BRAF, IRS2 copy number gain, InsR/IGF-IR overexpression, InsR/IGF-IR pathway activation, PTEN loss, CD24, mesenchymal markers, -catenin/TCF activity, FUS-DDIT3 fusion, and ERG [192,193,194,195,196,197,198,199,200,201]
For example: confusion, numbness and unsteadiness
Circadian Variation of Melatonin, Light Exposure, and Diurnal Preference in Day and Night Shift Workers of Both Sexes. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, vol
doi: 10.1007/s00430-008-0105-2 175 LiJ.PfefferS
