The secondary research was used to obtain critical information on the industrys value chain, the total pool of key players, market classification, and segmentation from the market and technology-oriented perspectives
418 Rechallenge strategies, by contrast, operate under the premise of clonal evolution reversibility, whereby reintroducing previously used agents, often after a drug holiday, can resensitize tumors due to regrowth of drug-sensitive clones
however, the progression from low-grade PanINs to PDAC involves sustained proliferation leading to the accumulation of somatic mutations and typically spans for longer than a decade 20,31
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