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Hydration/GI : nausea, vomiting, diarrhoea, reduced intakegiven explicit dehydration precautions in EU/US documents

Most patients across data sources were on another GLD in the 6 months before the index date, and metformin was the most commonly prescribed drug in all data sources, with the exception of J-CKD-DB-Ex, in which DPP-4 s were the most prescribed before index

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The trace element is a central cofactor for certain enzymes (glutathione peroxidases) that are responsible for the antioxidant function of glutathione