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Digestive side effects like nausea, diarrhea, and constipation were more common at the beginning of treatment (during the 36-week lead-in period of the trial, when everyone knew they were receiving the medicine)

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FOXO4 should be capable of continuing to play a vital role in the transcription of genes for antioxidant enzymes, such as manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX)