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Testosterone therapy can help preserve muscle, boost motivation, and support metabolism while semaglutide handles appetite and fat reduction

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A unique 'bystander effect' occurs wherein senescence extends beyond intracellular impacts as primary senescent cells secrete bioactive signals that alter the microenvironment, thereby inducing secondary senescence in neighboring or distant non-senescent cells through distinct mechanisms (such as autocrine, paracrine and juxtacrine) (20)

For those who do stop, how they come off the medication matters

PCOS is deeply intertwined with insulin resistance and excess fat storage, both of which suppress normal ovulation and cause chronic cycle irregularity