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To overcome the rapid degradation of GLP-1, two approaches have been developed: 1) GLP-1 receptor agonists resistant to DPP-IV metabolism, and 2) DPP-IV inhibitors to augment the effect of native/endogenous GLP-1
doi:10.1155/2023/9946924 Available from: Disclaimer : The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition
Triple-hormone-receptor agonists were further engineered by incorporating three amino acid substitutions/modifications starting from the sequence of our previously designed co-agonist peptide MDD GR , with the incorporation of an additional extended C-terminus (Fig
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