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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before
J Natl Cancer Inst (2000) 92(18):147289
Ford, W
Many clients notice an energy boost within a few hours, though results vary individually
The FDA has received adverse event reports associated with compounded semaglutide products
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