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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)

This early period is primarily about protocol establishment, tolerance assessment, and getting both compounds into a consistent daily routine

Moreover, M that undergoes metabolic reprogramming causes the accumulation of intermediate metabolites (124, 209213)

SCD1 catalyzes the desaturation of palmitic acid (16:0) into palmitoleic acid (16:1) and stearic acid (18:0) into oleic acid (18:1) 48

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