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K., Krarup, T., Vlund, A., Holst, J

Patients often describe a sensation of fullness or mild queasiness, which usually improves within several weeks as tolerance develops

This lactic acid buildup in the muscles and brain is a primary driver of the heavy, burning muscle pain and profound cognitive fatigue experienced during post-exertional malaise (PEM)

Given the small absolute event rates, VTE considerations are unlikely to be a primary driver of treatment selection, but may provide reassurance regarding safety in patients at elevated thrombotic risk

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