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In the SURMOUNT-2 study, which involved 938 adults with obesity or overweight and T2D, tirzepatide showed significant weight loss effects of 13.4% and 15.7% for the 10 and 15 mg doses, respectively, with over 80% of participants experiencing at least a 5% weight loss [92]
Cowie CC, Casagrande SS, Menke A (2018) Diabetes in America
Doi: National-Institute-for-Health-and-Care-Excellence
In the vascular wall, it functions as an enzyme modulator that upregulates eNOS and downregulates NADPH oxidase
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