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Ex-4 also promotes brain-derived insulin production and enhances insulin signaling through the Wnt/-catenin/NeuroD1 signaling pathway, which subsequently reduces tau hyperphosphorylation and cognitive dysfunction in diabetic mice [64]
Therefore, further large-scale studies are needed to further explore the therapeutic efficacy of GLP-1R agonists in patients with DPN
Food and Drug Administration Compounded GLP-1 medications can often be accessed through telehealth services that work with state-licensed compounding pharmacies, which ship directly to patients
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