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Some are approved for human use: Insulin is a peptide
GLP-1 agonists work primarily through gut-brain signaling and slowed gastric emptying
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Additive effect on kidney outcomes including macroalbuminuria was also expected from AMPLITUDE-O substudy, however, additive effect of semaglutide and SGLT2i on the composite kidney outcomes without macroalbuminuria was not indicated in the FLOW substudy [50]
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