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Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial
Firstly, the delivery method: existing trials have universally relied on systemic (oral or IV) administration, a route likely too slow and diffuse to counter the rapid oxidative burst in the reperfusing heart, while a more direct intracoronary approach has never been tested
Similarly, low carnitine levels mean there's not enough of this essential amino acid derivative to bind with fatty acids, and the transport of fatty acids into the mitochondria decreases
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