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Studies indicate that long-term metformin use can reduce serum B12 blood test levels by up to 20%, necessitating regular monitoring and preventive B12 supplementation protocols

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Glucose hexaphosphate, produced from glycogen breakdown, is processed through the pentose phosphate pathway, regulating ROS levels via the NADPH-glutathione system [44]

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308 Compared with those in normal tissues, the levels of MDM2 and herpesvirus-associated ubiquitin-specific protease (HAUSP), which is an enzyme that targets p53 for deubiquitination, are significantly increased