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Thus, key metabolic and neurobehavioral dysregulations of BBS were effectively recapitulated in Bbs5 / mice, which offer a robust platform for dissecting BBS pathophysiology and developing potential therapeutic strategies

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Study population We included all patients registered as having type 2 diabetes in the National Diabetes Register who filled their first prescription for a GLP-1 receptor agonist, and, in a separate cohort, all patients registered as having type 2 diabetes in the National Diabetes Register who filled their first prescription for an SGLT2 inhibitor, between 1 January 2017 and 31 December 2021 (ensuring a minimum of 1-year follow-up until the end of the study period on 31 December 2022)

More serious side effects, such as pancreatitis or gallbladder disease, are rare but should be carefully considered, especially for individuals with a history of these conditions

Keep in mind that insurance coverage will vary by plan, and some plans may not cover these medications if they are being used off-label